
The museum was established in 2002 by Theresa Turner Burroughs (1929-2019), a Greensboro beautician and organizer who was among the group who secured King in the house. The main building in which the museum is housed a shotgun home built for workers at the local cotton gin at the turn of the twentieth century. The architectural style is so called because all the rooms open on to each other from the front to the back, and a person could shoot a shotgun through the front door and out the back door with no obstruction. The Burroughs family purchased the property, which included three houses, in the 1940s, and Burroughs's mother, Mattie, lived in the building that now houses the museum.
One of eleven children, Burroughs was a childhood acquaintance of Coretta Scott King, and they attended the same church. Burroughs had a history as a foot soldier in the civil rights movement; she was arrested six times and was among the first group of people to cross the Edmund Pettus Bridge in Selma during the Selma to Montgomery march. She also helped found the Hale County Civic Improvement League and provided space for West Alabama Health Services, a medical office that catered to underserved communities.

In the late 1990s, Borroughs decided that she wanted to create a space to share Greensboro's civil rights history and commemorate the town's role in saving King's life that evening. She had numerous photographs and documents and began gathering materials from friends in the movement as well. Among the many photographs in the museum is a large collection of black-and-white mug shots of marchers as well as one of Burroughs trying to protect herself from teargas on the Pettus Bridge. Other items include household and farm implements and musical instruments owned and donated by local families that give visitors a view of life in late nineteenth and early twentieth century Hale County.

Burroughs died on May 22, 2019, and the following week, Alabama congresswoman Terri Sewell honored her legacy on the floor of the U.S. Congress in a speech that was entered into the Congressional Record. Current director Theresa Davis took over after Burroughs's death, and the operations are overseen by a board of directors. The museum is open for tours by appointment only.