Limestone County was created from former Chickasaw and Cherokee Indian land in February 1818. The oldest operational post office in the state has been in its current building, in Mooresville, since around 1840. A train depot in Athens, the county seat, houses the Alabama Veterans Museum and Archives. During the Civil War, the county experienced numerous skirmishes including the Battle of Sulphur Trestle and the Sack of Athens. Fort Henderson, an earthen structure, was constructed by U.S. Colored Troops in 1864. The site later became the state’s first high school for African American students. The Donnell House was used by the Union Army to quarter soldiers.