Clarke County was created in December 1812, when the region was part of the Mississippi Territory. The county lies between the Tombigbee River, which flows along the western edge, and the Alabama River, which runs along the eastern edge. The two rivers meet and form the Mobile River at the county’s southern end. The Clarke County Historical Museum, in Grove Hill, displays many artifacts and historical items, including prehistoric whale fossils. The Kathryn Windham Tucker Museum, which honors renowned the Alabama storyteller, is located at Alabama Southern Community College in Thomasville.