
The depot is similar to other train stations constructed by the Central of Georgia Railroad Company in the 1890s and many other buildings in rural communities. It is a one-story wooden building with a gabled roof and board-and-batten siding. The building consists of three rooms: two front rooms used for passenger waiting rooms and a rear freight room that takes up the rest of the building. The two waiting rooms have separate entrances, a reflection of their construction during the era of legal segregation. African Americans used the room in the back of the building and whites used the front room. All the windows have security bars attached to them. The agent's office, which connects the two waiting-room structures, has a gabled bay window.

The railroad depot was built in 1899 after local businessmen offered a $5,000 prize for the first railroad to construct a line into the town, and J. M. Prestwood donated five acres of land for the depot. On September 20, 1899, the Central of Georgia Railroad Company completed construction, besting the Alabama-Florida Railroad Company for the prize. The depot prompted increased business development and population growth in Andalusia. The population doubled in one year and continued to increase as commerce in lumber, timber, agricultural products, and the turpentine industry, also expanded. The railroad continued operation until March 31, 1983, when the last train, owned by the Norfolk Southern Company, departed from the station.

The museum is located on Historical Central Street at the corner of Tisdale Street and is open from 9:00 a.m. to 2:00 p.m. Monday, Tuesday, and Wednesday. It is free but welcomes donations. Large groups are encouraged to call ahead for an appointment. Nearby are Springdale Estate and numerous other places of interest in Andalusia, including a historic commercial district that was added to the National Register of Historic Places in 1988. Also on the Register are the Old First National Bank (ca. 1901) and the Covington County Courthouse and Jail (ca. 1914).