
Bryce was born in Columbia, South Carolina, to Peter and Martha Smith Bryce. He graduated with distinction from The Citadel in 1855 and New York's Medical College (now New York University School of Medicine) in 1859. After graduating, Bryce travelled in Europe, where his developing interest in mental health was enhanced during visits to psychiatric hospitals. Upon his return, he worked at psychiatric hospitals in New Jersey and South Carolina.
In late 1859, Dorothea Dix, a teacher and nationally renowned advocate for the mentally ill, brought Bryce to the attention of the trustees of the Alabama Insane Hospital (AIH). Located in Tuscaloosa, the institution had been created by the state legislature in 1852 but remained under construction for most of the decade. Despite his youth, Bryce's training and southern roots were viewed favorably by the trustees, and in July 1860 they selected him to be the hospital's first superintendent. Bryce accepted and moved to Tuscaloosa soon after marrying Ellen Clarkson, also of Columbia. The childless couple would devote all of their attention to AIH for the next 30 years. As construction was completed, Bryce developed the institutional policies and procedures by which the hospital was governed. As a public institution, AIH's finances were constrained by perpetual state budget shortfalls, and the hospital was perennially underfunded.

Bryce extolled the therapeutic value of work—often arguing that idle hands allowed mental patients too much time to focus on their condition—and pragmatically recognized patient labor as essential to AIH's economic survival in the face of diminishing state funds and a patient population that, over the period of his superintendence, averaged 85 percent indigents. Income derived from the patients' vegetable garden and the manufacture of household goods became an important supplement to state support.

Bryce's life was so intricately entwined with the AIH that at his death from Bright's Disease on August 14, 1892, he was buried on the hospital grounds, and AIH was later renamed Bryce Hospital.
Additional Resources
Owen, Thomas M. "Peter Bryce." In History of Alabama and Dictionary of Alabama Biography. 4 vols. Chicago: S. J. Clarke, 1921.
Additional Resources
Owen, Thomas M. "Peter Bryce." In History of Alabama and Dictionary of Alabama Biography. 4 vols. Chicago: S. J. Clarke, 1921.
Weaver, Bill. "Establishing and Organizing the Alabama Insane Hospital, 1846-1861." Alabama Review 47 (July 1995): 219–32.
———. "Survival at the Alabama Insane Hospital, 1861–1892." Journal of the History of Medicine and Allied Sciences 51 (January 1996): 5–28.