
Wynette was born Virginia Wynette Pugh on May 5, 1942, on a farm outside Tremont, Mississippi. She was the only child of Mildred Faye Russell, an office worker and substitute teacher, and William Hollice Pugh, a farmer and musician. Wynette's father died when she was nine months old, and her mother left her to be raised by her parents, Thomas and Flora Russell, whose farm straddled the border with Alabama; the rural home had no indoor plumbing. Wynette had a natural gift for music and taught herself to play her father's instruments, which her mother had brought to the home as well. Throughout her childhood, Wynette spent many days in Red Bay shopping and going to the movies and visiting relatives who lived in the town. Wynette attended Tremont High School, where she was a leading scorer on the school's basketball team, and she played piano and sang at her local church. A few months before graduation in 1960, Wynette married local construction worker Euple Byrd, with whom she would have three daughters. Byrd changed jobs frequently, and the family moved often. In 1963, Wynette graduated from a beauty school in Tupelo, Mississippi, and became a licensed hair dresser. Harboring dreams of becoming a singer, Wynette performed at local nightclubs in Tupelo at night.
Around 1964, just before the birth of her third daughter, Wynette divorced Byrd and moved to Alabama, living in the Elyton Village housing project outside Birmingham, where she worked for several years as a beautician. She had not given up her dream of being a singer and performed in the evenings at local bars. In 1965, she came to the attention of the producers of the Country Boy Eddie Show, a morning television program that often highlighted unknown local musicians. Wynette's singing talents earned her a regular spot on the show, and she rose early to perform and then went to her hairdresser's job for the rest of the day. Hoping to increase her chances of a recording career, she traveled to Nashville, the mecca for country musicians, several times seeking a contract and soon came to the attention of Grand Ole Opry star Porter Wagoner, who featured her on his nationally syndicated television series. She moved to Nashville with her daughters in 1966 and was signed to Epic Records by fellow Alabamian Billy Sherrill. It was at this time that she officially changed her name to Tammy Wynette, chosen for lead female character in the 1957 film Tammy and the Bachelor.

The 1980s saw a decline in Wynette's sales and chart successes, although four of her singles reached the top 20 of the country charts. In 1985, she performed with George Jones at the inaugural gala of the Alabama Music Hall of Fame at Boutwell Auditorium in Birmingham. Plagued by various health problems, including several surgeries, Wynette became addicted to pain medication and was admitted to the Betty Ford Clinic rehab facility in 1986. The following year, however, she was given a recurring role on the soap opera Capitol, and the three albums she released during this decade—Sometimes When We Touch, Higher Ground, and Next to You—had decent sales. In 1988, she was forced to declare bankruptcy over failed investments. In 1990, Wynette returned to Red Bay for a ceremony dedicating a section of State Highway 3, which Wynette traveled frequently between Tremont and Red Bay, as the Tammy Wynette Highway.

In 2012, Wynette was again the subject of controversy when her stepdaughter, Richey's daughter, removed the plaque on her crypt and replaced it with one bearing Wynette's married name: Virginia W. Richardson. Wynette's other children decried the change and also have been involved in efforts to sue for shares of their mother's estate.
Tammy Wynette is remembered and celebrated in her adopted hometown of Red Bay at the Red Bay Museum, which houses a large collection of Wynette memorabilia, costumes, and other items donated by her daughters.