
Freddie Dalton Thompson was born on August 19, 1942, in Sheffield, Colbert County, to Ruth Inez Bradley Thompson and Fletcher Session Thompson, a car salesman. Thompson attended public schools in Sheffield, but his family moved to Lawrenceburg, Tennessee, by the time Freddie was of high-school age, and he attended Lawrence County High School there. The 6'5" Thompson played football and basketball for the school. Thompson married Sarah Elizabeth Lindsey in 1959 while still in high school, resulting in Thompson being banned from participating in school sports. The couple had one daughter and two sons. They would divorce in 1985.
In 1960, Thompson moved his family to Alabama so that he could attend Florence State College (present-day University of North Alabama), in Colbert County, but he transferred to Memphis State University two years later, graduating in 1964 with a double major in political science and philosophy. Thompson then earned a law degree from Vanderbilt University and was admitted to the Tennessee State Bar in 1967 and shortened his name to Fred. He credited his uncle's gift of the autobiography of the Scopes "monkey" trial lawyer Clarence Darrow with inspiring him to attend law school.

Thompson's acting career began through a 1977 case in which he represented Marie Ragghianti, chair of the Tennessee Board of Pardons and Paroles, in her successful wrongful termination suit against the state governor's office. Ragghianti was fired for refusing to release prisoners pardoned by Gov. Ray Blanton after she discovered that they had paid bribes to his aides in return for parole. Her experience was recounted in the 1983 book Marie: A True Story by journalist Peter Maas and the 1985 film version Marie, with Thompson playing himself in the role of her attorney opposite Sissy Spacek as Ragghianti. A natural in front of the camera, Thompson earned a role in the Kevin Costner/Gene Hackman film No Way Out (1987), which led to additional film roles and television guest spots on popular shows such as Roseanne and China Beach. In 1990, he starred in three of the year's highest-grossing films: The Hunt for Red October, Days of Thunder, and Die Hard 2. By 2002, he had earned role as a regular on the legal procedural series Law & Order and its spinoffs, Law & Order: Special Victims Unit and Law & Order: Trial by Jury, which would continue until 2007. He continued to act in film and television until his death.
In addition to his legal practice, Thompson worked as a lobbyist from 1975 until he began his Senate campaign in 1993. His clients included manufacturer Westinghouse, the Teamsters Union, and the Tennessee Savings and Loan League. His efforts on their behalf helped gain the passage of the federal Garn-St. Germain Depository Institutions Act of 1982, which deregulated the savings and loan industry and led to many failed financial institutions beginning in the mid-1980s.
In 1993, Tennessee senator Al Gore resigned from the seat to serve as vice-president in the administration of Pres. Bill Clinton. Thompson mounted a campaign for the seat and garnered media attention for renting a red pickup truck to take on the campaign trail. In the 1994 election, he defeated the Democratic candidate, Congressman Jim Cooper, in a landslide. Thompson was re-elected to a full term two years later. During his time in the Senate, Thompson was a proponent of campaign finance reform, nuclear disarmament, and reducing government waste and inefficiency. During the 1999 vote to impeach Pres. Clinton, Thompson was one of 44 senators who voted against the measure. He served on the Committee on Governmental Affairs, being named chair in 1997, as well as on the Judiciary Committee, the Foreign Relations Committee, and the Special Committee on Aging, and he chaired the Subcommittee on Youth Violence and the Subcommittee on International Policy, Export, and Trade Promotion. In 2000, he was co-chair of the committee to elect Arizona senator John McCain president and was among those considered as a running mate by George W. Bush after he won the Republican primary.

In 2007, announced that he would be a Republican candidate for president in the 2008 election cycle and also disclosed publicly that he had been diagnosed with non-Hodgkin's lymphoma in 2004 but was in remission. He never earned higher than third in polling and dropped out in January 2008. He then threw his support behind John McCain once again. He was one of the featured speakers at the Republican National Convention in September of that year. After the election, he returned to radio and television, becoming the national spokesman for reverse-mortgage lender American Advisors Group. In 2010, he published a memoir, Teaching the Pig to Dance: A Memoir of Growing Up and Second Chances.
Thompson died on November 1, 2015, of complications related to cancer. He was buried in Mimosa Cemetery in Lawrenceburg, Tennessee.