
The Lutheran Church-Missouri Synod was formed by German immigrants from Saxony (in present-day Germany) in the 1830s to escape religious persecution by the authorities. Upon arriving in the United States, they travelled up the Mississippi River and settled for the most part in rural Missouri (Perry County), hence the "Missouri" in the name. Not all these individuals, however, decided to settle in the rural Midwest. Some elected to stay in the southern port cities where they first docked, including New Orleans, Louisiana, and Mobile, Alabama.

Other churches founded in the greater Mobile area were formed by missionaries of the Lutheran Church–Missouri Synod and its regional entity, known as the Southern District and organized in 1882. Congregations established within the district over the next decades include St. Mark in Alberta (1908), St. Paul in Foley (1912), and Redeemer in Fairhope (1949). In metropolitan Mobile, the Holy Cross and Our Savior congregations were founded in 1959 and 1964, respectively.

In north-central Alabama, Lutherans were drawn to the area by John G. Cullman, a former officer in the German Army who bought much land in the region. He persuaded German families to settle that area of Alabama which later became the city of Cullman. In 1880, the Missouri Synod sent missionary Rev. Traugott Thieme into north Alabama to minister to the German immigrants. Traugott was replaced in 1884 by Rev. Carl Burkhart, who was commissioned to work with German families in the Garden City-Hanceville area of Cullman County. Rev. Ferdinand Englebert was sent to Cullman and organized the church of St. Paul in 1886. Another congregation was organized in Decatur 35 miles north of Cullman in 1898. New work on a church was begun in nearby Hartselle in 2000.

Mission work in Huntsville and northwest Alabama was centered around the Redstone Arsenal and the German engineers and scientists who settled into the area in the early 1950s. There are three congregations in Huntsville and one each in Florence and Muscle Shoals. In eastern and northeastern Alabama, congregations exist in Gadsden, Attalla, Scottsboro, Albertville, and Fort Payne. Montgomery has three LCMS congregations, as does Tuscaloosa. Three additional congregations were added to the Missouri Synod in the 1950s and 1960s from the former American Lutheran Church: Trinity (now United) in Montgomery, Christ in Tuscaloosa, and St. Paul in Birmingham.

The LCMS, together with the Evangelical Lutheran Church in America, operate a statewide social ministry agency known as Lutheran Ministries of Alabama (LMA), which provides a summer tutoring program for students in need and a visitation site in Cullman for children of divorced parents. The agency also is involved with Lutheran Disaster Response, which helps people throughout the United States who have been the victims of tornadoes, floods, and other natural disasters. LMA is a member of Alabama Arise, which advocates for the poor in Alabama, and Greater Birmingham Ministries, which provides food, clothing, and financial assistance to those in need.
Additional Resources
Dickinson, Richard C. Roses and Thorns: The Centennial Edition of Black Lutheran Mission and Ministry in the Lutheran Church-Missouri Synod. St. Louis: Concordia Publishing House, 1977.
Additional Resources
Dickinson, Richard C. Roses and Thorns: The Centennial Edition of Black Lutheran Mission and Ministry in the Lutheran Church-Missouri Synod. St. Louis: Concordia Publishing House, 1977.
Ertl, James, ed. God's Amazing Grace: A Centennial History of the Southern District of the Lutheran Church Missouri Synod. Southern District Centennial Committee, 1982.
The Lutheran Witness (Southern Edition inserts). St. Louis, Mo: Concordia Publishing House, April 1953 through June 1964.